Mitosis: Springtime for Chromatin
نویسندگان
چکیده
منابع مشابه
Mitosis: Springtime for Chromatin
When a eukaryotic cell divides, tension builds at centromeres as spindle forces pull chromosomes toward opposite poles during metaphase. New data show that centromeric chromatin stretches in response to these forces, revealing a mechanical role for chromatin packaging in mitosis.
متن کاملPericentric Chromatin Is Organized into an Intramolecular Loop in Mitosis
BACKGROUND Cohesin proteins link sister chromatids and provide the basis for tension between bioriented sister chomatids in mitosis. Cohesin is concentrated at the centromere region of the chromosome despite the fact that sister centromeres can be separated by 800 nm in vivo. The function of cohesin at sites of separated DNA is unknown. RESULTS We provide evidence that the kinetochore promote...
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Metaphase chromosomes are visible hallmarks of mitosis, yet our understanding of their structure and of the forces shaping them is rudimentary. Phosphorylation of histone H3 serine 10 (H3 S10) by Aurora B kinase is a signature event of mitosis, but its function in chromatin condensation is unclear. Using genetically encoded ultraviolet light-inducible cross-linkers, we monitored protein-protein...
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Histone modifications have been associated with particular states of transcriptional activity and are thought to serve as an "information code". However, this principle does not apply to histone phosphorylation, which can be detected in two, seemingly contrasting situations, i.e., in a transcriptionally hyperactive state following growth factor stimulation and in transcriptionally paused mitoti...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2007
ISSN: 0960-9822
DOI: 10.1016/j.cub.2007.04.019